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| also: | Kentucky Intercollegiate Ohio Valley |
| Year | Seed | Record | Finishing Round | Coach |
| 1940 | - | 0 - 1 | Elite Eight (1st rd) | Ed Diddle |
| 1960 | - | 2 - 1 | Sweet Sixteen (2nd rd) | Ed Diddle |
| 1962 | - | 1 - 2 | Sweet Sixteen (2nd rd) | Ed Diddle |
| 1966 | - | 2 - 1 | Sweet Sixteen (2nd rd) | Johnny Oldham |
| 1967 | - | 0 - 1 | Round of 32 (1st rd) | Johnny Oldham |
| 1970 | - | 0 - 1 | Round of 32 (1st rd) | Johnny Oldham |
| 1971 | - | 4 - 1 | National Semifinals (4th rd) | Johnny Oldham |
| 1976 | - | 0 - 1 | Round of 32 (1st rd) | Jim Richards |
| 1978 | - | 1 - 1 | Sweet Sixteen (2nd rd) | Jim Richards |
| 1980 | 10 | 0 - 1 | Round of 64 (1st rd) | Gene Keady |
| 1981 | 10 | 0 - 1 | Round of 64 (1st rd) | Clem Haskins |
| 1986 | 8 | 1 - 1 | Round of 32 (2nd rd) | Clem Haskins |
| 1987 | 10 | 1 - 1 | Round of 32 (2nd rd) | Murray Arnold |
| 1993 | 7 | 2 - 1 | Sweet Sixteen (3rd rd) | Ralph Willard |
| 1994 | 11 | 0 - 1 | Round of 64 (1st rd) | Ralph Willard |
| 1995 | 8 | 1 - 1 | Round of 32 (2nd rd) | Matt Kilcullen |
| 2001 | 14 | 0 - 1 | Round of 64 (1st rd) | Dennis Felton |
| 2002 | 9 | 0 - 1 | Round of 64 (1st rd) | Dennis Felton |
| 2003 | 13 | 0 - 1 | Round of 64 (1st rd) | Dennis Felton |
| 2008 | 12 | 2 - 1 | Sweet Sixteen (3rd rd) | Darrin Horn |
| 2009 | 12 | 1 - 1 | Round of 32 (2nd rd) | Ken McDonald |
