Southern Illinois NCAA Tournament Results
Tournament Record: 6 - 10
Current Conference: Missouri Valley
| Year | Seed | Record | Finishing Round | Coach |
| 1977 | - | 1 - 1 | Sweet Sixteen (2nd rd) | Paul Lambert |
| 1993 | 14 | 0 - 1 | Round of 64 (1st rd) | Rich Herrin |
| 1994 | 11 | 0 - 1 | Round of 64 (1st rd) | Rich Herrin |
| 1995 | 10 | 0 - 1 | Round of 64 (1st rd) | Rich Herrin |
| 2002 | 11 | 2 - 1 | Sweet Sixteen (3rd rd) | Bruce Weber |
| 2003 | 11 | 0 - 1 | Round of 64 (1st rd) | Bruce Weber |
| 2004 | 9 | 0 - 1 | Round of 64 (1st rd) | Matt Painter |
| 2005 | 7 | 1 - 1 | Round of 32 (2nd rd) | Chris Lowery |
| 2006 | 11 | 0 - 1 | Round of 64 (1st rd) | Chris Lowery |
| 2007 | 4 | 2 - 1 | Sweet Sixteen (3rd rd) | Chris Lowery |
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