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| also: | Big East Independent Metro Missouri Valley |
| Year | Seed | Record | Finishing Round | Coach |
| 1951 | - | 0 - 1 | Sweet Sixteen (1st rd) | Peck Hickman |
| 1959 | - | 3 - 2 | National Semifinals (4th rd) | Peck Hickman |
| 1961 | - | 2 - 1 | Sweet Sixteen (2nd rd) | Peck Hickman |
| 1964 | - | 0 - 1 | Round of 32 (1st rd) | Peck Hickman |
| 1967 | - | 0 - 2 | Sweet Sixteen (2nd rd) | Peck Hickman |
| 1968 | - | 1 - 1 | Sweet Sixteen (2nd rd) | John Dromo |
| 1972 | - | 2 - 2 | National Semifinals (4th rd) | Denny Crum |
| 1974 | - | 0 - 2 | Sweet Sixteen (2nd rd) | Denny Crum |
| 1975 | - | 4 - 1 | National Semifinals (4th rd) | Denny Crum |
| 1977 | - | 0 - 1 | Round of 32 (1st rd) | Denny Crum |
| 1978 | - | 1 - 1 | Sweet Sixteen (2nd rd) | Denny Crum |
| 1979 | 3 | 1 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1980 | 2 | 5 - 0 | National Championship (6th rd) | Denny Crum |
| 1981 | 4 | 0 - 1 | Round of 32 (2nd rd) | Denny Crum |
| 1982 | 3 | 3 - 1 | National Semifinals (5th rd) | Denny Crum |
| 1983 | 1 | 3 - 1 | National Semifinals (5th rd) | Denny Crum |
| 1984 | 5 | 2 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1986 | 2 | 6 - 0 | National Championship (6th rd) | Denny Crum |
| 1988 | 5 | 2 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1989 | 4 | 2 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1990 | 4 | 1 - 1 | Round of 32 (2nd rd) | Denny Crum |
| 1992 | 8 | 1 - 1 | Round of 32 (2nd rd) | Denny Crum |
| 1993 | 4 | 2 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1994 | 3 | 2 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1995 | 11 | 0 - 1 | Round of 64 (1st rd) | Denny Crum |
| 1996 | 6 | 2 - 1 | Sweet Sixteen (3rd rd) | Denny Crum |
| 1997 | 6 | 3 - 1 | Elite Eight (4th rd) | Denny Crum |
| 1999 | 7 | 0 - 1 | Round of 64 (1st rd) | Denny Crum |
| 2000 | 7 | 0 - 1 | Round of 64 (1st rd) | Denny Crum |
| 2003 | 4 | 1 - 1 | Round of 32 (2nd rd) | Rick Pitino |
| 2004 | 10 | 0 - 1 | Round of 64 (1st rd) | Rick Pitino |
| 2005 | 4 | 4 - 1 | National Semifinals (5th rd) | Rick Pitino |
| 2007 | 6 | 1 - 1 | Round of 32 (2nd rd) | Rick Pitino |
| 2008 | 3 | 3 - 1 | Elite Eight (4th rd) | Rick Pitino |
| 2009 | 1 | 3 - 1 | Elite Eight (4th rd) | Rick Pitino |
| 2010 | 9 | 0 - 1 | Round of 64 (1st rd) | Rick Pitino |
