| Year | Seed | Record | Finishing Round | Coach |
| 1942 | - | 1 - 1 | National Semifinals (2nd rd) | Adolph Rupp |
| 1945 | - | 1 - 1 | Elite Eight (1st rd) | Adolph Rupp |
| 1948 | - | 3 - 0 | National Championship (3rd rd) | Adolph Rupp |
| 1949 | - | 3 - 0 | National Championship (3rd rd) | Adolph Rupp |
| 1951 | - | 4 - 0 | National Championship (4th rd) | Adolph Rupp |
| 1952 | - | 1 - 1 | Elite Eight (2nd rd) | Adolph Rupp |
| 1955 | - | 1 - 1 | Sweet Sixteen (2nd rd) | Adolph Rupp |
| 1956 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1957 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1958 | - | 4 - 0 | National Championship (5th rd) | Adolph Rupp |
| 1959 | - | 1 - 1 | Sweet Sixteen (2nd rd) | Adolph Rupp |
| 1961 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1962 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1964 | - | 0 - 2 | Sweet Sixteen (2nd rd) | Adolph Rupp |
| 1966 | - | 3 - 1 | National Championship (5th rd) | Adolph Rupp |
| 1968 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1969 | - | 1 - 1 | Sweet Sixteen (2nd rd) | Adolph Rupp |
| 1970 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1971 | - | 0 - 2 | Sweet Sixteen (2nd rd) | Adolph Rupp |
| 1972 | - | 1 - 1 | Elite Eight (3rd rd) | Adolph Rupp |
| 1973 | - | 1 - 1 | Elite Eight (3rd rd) | Joe Hall |
| 1975 | - | 4 - 1 | National Championship (5th rd) | Joe Hall |
| 1977 | - | 2 - 1 | Elite Eight (3rd rd) | Joe Hall |
| 1978 | - | 5 - 0 | National Championship (5th rd) | Joe Hall |
| 1980 | 1 | 1 - 1 | Sweet Sixteen (3rd rd) | Joe Hall |
| 1981 | 2 | 0 - 1 | Round of 32 (2nd rd) | Joe Hall |
| 1982 | 6 | 0 - 1 | Round of 64 (1st rd) | Joe Hall |
| 1983 | 3 | 2 - 1 | Elite Eight (4th rd) | Joe Hall |
| 1984 | 1 | 3 - 1 | National Semifinals (5th rd) | Joe Hall |
| 1985 | 12 | 2 - 1 | Sweet Sixteen (3rd rd) | Joe Hall |
| 1986 | 1 | 3 - 1 | Elite Eight (4th rd) | Eddie Sutton |
| 1987 | 8 | 0 - 1 | Round of 64 (1st rd) | Eddie Sutton |
| 1988 | 2 | 2 - 1 | Sweet Sixteen (3rd rd) | Eddie Sutton |
| 1992 | 2 | 3 - 1 | Elite Eight (4th rd) | Rick Pitino |
| 1993 | 1 | 4 - 1 | National Semifinals (5th rd) | Rick Pitino |
| 1994 | 3 | 1 - 1 | Round of 32 (2nd rd) | Rick Pitino |
| 1995 | 1 | 3 - 1 | Elite Eight (4th rd) | Rick Pitino |
| 1996 | 1 | 6 - 0 | National Championship (6th rd) | Rick Pitino |
| 1997 | 1 | 5 - 1 | National Championship (6th rd) | Rick Pitino |
| 1998 | 2 | 6 - 0 | National Championship (6th rd) | Tubby Smith |
| 1999 | 3 | 3 - 1 | Elite Eight (4th rd) | Tubby Smith |
| 2000 | 5 | 1 - 1 | Round of 32 (2nd rd) | Tubby Smith |
| 2001 | 2 | 2 - 1 | Sweet Sixteen (3rd rd) | Tubby Smith |
| 2002 | 4 | 2 - 1 | Sweet Sixteen (3rd rd) | Tubby Smith |
| 2003 | 1 | 3 - 1 | Elite Eight (4th rd) | Tubby Smith |
| 2004 | 1 | 1 - 1 | Round of 32 (2nd rd) | Tubby Smith |
| 2005 | 2 | 3 - 1 | Elite Eight (4th rd) | Tubby Smith |
| 2006 | 8 | 1 - 1 | Round of 32 (2nd rd) | Tubby Smith |
| 2007 | 8 | 1 - 1 | Round of 32 (2nd rd) | Tubby Smith |
| 2008 | 11 | 0 - 1 | Round of 64 (1st rd) | Billy Gillespie |
| 2010 | 1 | 3 - 1 | Elite Eight (4th rd) | John Calipari |
